Calcium alginate microparticles containing anti-TB drugs
نویسندگان
چکیده
منابع مشابه
Inhalable microparticles containing large payload of anti-tuberculosis drugs.
Microparticles containing large payloads of two anti-tuberculosis (TB) drugs were prepared and evaluated for suitability as a dry powder inhalation targeting alveolar macrophages. A solution containing one part each of isoniazid and rifabutin, plus two parts poly(lactic acid) (L-PLA) was spray-dried. Drug content and in vitro release were assayed by HPLC, and DSC was used to elucidate release b...
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New drugs and drug combinations are urgently needed for shorter, more effective TB treatment. Standard regimens require treatment for at least 6 months and are difficult to complete in resource-constrained settings. Resistance to firstand second-line drugs is increasing in many areas and therefore drugs with new mechanisms of action are needed. These issues complicate clinical trials of new ant...
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متن کامل
Using a microfluidic chip and internal gelation reaction for monodisperse calcium alginate microparticles generation.
In this paper, the manipulation of monodisperse Ca-alginate microparticles using a microfluidic chip and a reaction of internal gelation is presented. Our strategy is based on the sheath focusing effect to form uniform water-in-oil (w/o) emulsions in the cross-junction microchannel. These fine emulsions, consisting of 1.5 % w/v Na-alginate and 1.0 % w/v calcium carbonate, are then dripped into ...
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ژورنال
عنوان ژورنال: Chemical Bulletin of Kazakh National University
سال: 2015
ISSN: 2312-7554,1563-0331
DOI: 10.15328/cb562